Reshaping Enzymes for New Chemical Space

The Huang Group develops photobiocatalytic and electroenzymatic platforms for mild, selective, and sustainable asymmetric synthesis.

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Research

Our research integrates biocatalysis, photochemistry, electrochemistry, and protein engineering to develop new catalytic strategies for asymmetric synthesis.

Enzymes × Light × Electricity Chiral Molecules

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Biocatalysis Photobiocatalysis Electroenzymatic catalysis Synthetic biology Asymmetric synthesis

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Selected Publications

All publications

A light-driven enzymatic enantioselective radical acylation.

Xu, Y.; Chen, H.; Yu, L.; Peng, X.; Zhang, J.; Xing, Z.; Bao, Y.; Liu, A.; Zhao, Y.; Tian, C.*; Liang, Y.*; Huang, X.* Nature 2024, 625, 74–78.

Graphical abstract for light-driven enzymatic radical acylation

Synergistic photobiocatalysis for enantioselective triple radical sorting.

Xing, Z.; Liu, F.; Feng, J.; Yu, L.; Wu, Z.; Zhao, B.; Chen, B.; Ping, H.; Xu, Y.; Liu, A.; Zhao, Y.; Wang, C.; Wang, B.*; Huang, X.* Nature 2025, 637, 1118–1123.

Graphical abstract for synergistic triple radical sorting

Electricity-driven enzymatic dynamic kinetic oxidation.

Zhao, B.; Xu, Y.; Zhu, Q.; Liu, A.; Peng, X.; Zhang, T.; Yu, L.; Zhang, Y.; Huang, X.* Nature 2025, 643, 699–704.